Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Hypercitrullination
- Molecular classification
- Post-translational modification, Protein modification, Enzymatic process
01
Overview
Hypercitrullination is the excessive citrullination of multiple intracellular proteins, primarily in immune cells, driven by overactivation of peptidylarginine deiminase (PAD) enzymes. This process is often triggered by a rapid influx of calcium ions into the cell cytoplasm, frequently due to membranolytic pathways like the perforin-granzyme pathway or complement activation. Hypercitrullination is implicated in the pathogenesis of rheumatoid arthritis, where it generates neoantigens that drive autoimmunity through the production of anti-citrullinated protein antibodies (ACPAs).
- Other names
- Cellular hypercitrullinationLeukotoxic hypercitrullinationExcessive protein citrullination
02
Mechanism of action
N/A (Hypercitrullination is a process, not a drug target with a defined mechanism of action.)
03
Biological functions
Protein modificationImmune response modulationNeoantigen generationCell death regulation (context-dependent)
04
Disease associations
Rheumatoid arthritisAutoimmunityInflammation
05
Safety considerations
Potential for off-target effects if targeting PAD enzymes directlyComplexity of modulating calcium influx without affecting other cellular processes
06
Interacting drugs
A23187
1 more in the full profile.
07
Biomarkers
Citrullinated proteins in synovial fluidAnti-citrullinated protein antibodies (ACPAs)
Beyond the preview
Go deeper on Hypercitrullination.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Hypercitrullination.