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Target intelligence / Profile preview
Hyperpolarization-Activated Cyclic Nucleotide-Gated Cation Channel (HCN)
- Target
- HCN
- Molecular classification
- Ion channel, Voltage-gated ion channel, Cyclic nucleotide-gated channel
01
Overview
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are nonselective voltage-gated cation channels primarily found in heart and brain cells. They are encoded by four genes (HCN1-4) and play a crucial role in controlling rhythmic electrical activity, such as cardiac pacemaking and neuronal excitability. HCN channels activate upon hyperpolarization and are further modulated by intracellular cyclic nucleotides (cAMP, cGMP, cCMP). Dysfunction of HCN channels is implicated in cardiac arrhythmias and neurological disorders, making them a therapeutic target for conditions like bradycardia, epilepsy, neuropathic pain, and depression.
- Other names
- Ih channelIf channel
02
Mechanism of action
Inhibition of HCN channel activity
03
Biological functions
Regulation of heart rateRegulation of neuronal excitabilityPacemakingSetting resting membrane potentialDendritic integrationSynaptic transmissionNeuronal rhythmogenesis
04
Disease associations
Cardiac arrhythmiasNeurological disordersEpilepsyNeuropathic painDepression
05
Safety considerations
Potential for cardiac side effects due to heart rate modulationPotential for neurological side effects due to altered neuronal excitability
06
Interacting drugs
Ivabradine
3 more in the full profile.
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