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Target intelligence / Profile preview
Hyperpolarization-activated cyclic nucleotide-gated channel (HCN channel)
- Target
- HCN channel
- Molecular classification
- Ion channel, Voltage-gated ion channel
01
Overview
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are a family of voltage-gated ion channels that play critical roles in regulating electrical activity in both the heart and nervous system. They are essential for generating rhythmic activity, particularly within cardiac pacemaker cells and certain neurons. HCN channels are unique among voltage-gated ion channels due to their dual regulation by membrane hyperpolarization and direct modulation via cyclic nucleotides. Their central role as pacemakers makes them vital targets for cardiovascular therapeutics as well as promising candidates for neurological disease intervention strategies.
- Other names
- Pacemaker channelI_f channelI_h channel
02
Mechanism of action
Inhibition of I_f current in cardiac pacemaker cells.
03
Biological functions
Cardiac pacemakingNeuronal excitabilityRhythmic firing patternsDendritic integrationSynaptic transmission modulationModulation of sleep-wake cyclesLearning and memory formationSensory perception (pain/vision)
04
Disease associations
Cardiac arrhythmiasEpilepsyNeuropathic pain syndromes
05
Interacting drugs
Ivabradine
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