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Hyperpolarization-activated Cyclic Nucleotide-gated Channel 1 (None)
- Target
- None
- Molecular classification
- Voltage-gated ion channel superfamily, Ion channel
01
Overview
Hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1) is a voltage-gated ion channel that opens in response to membrane hyperpolarization. It contributes to the generation of Ih/If currents, which regulate heart rate, neuronal excitability, and other physiological processes. HCN1 channels are modulated by intracellular cAMP levels, and their dysfunction has been linked to epilepsy, neuropathic pain, and neurodegenerative diseases. Several clinically relevant drugs, including ketamine, propofol, isoflurane, and sevoflurane, inhibit HCN1.
- Other names
- HCN1Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
02
Mechanism of action
Inhibition of HCN1 channel activity
03
Biological functions
Regulation of heart rateNeuronal excitabilityDendritic integrationSynaptic transmissionSleep-wake cyclesLearning/memory processesSomatic sensationGeneration of Ih/If currents
04
Disease associations
EpilepsyNeuropathic painNeurodegenerative diseases
05
Safety considerations
Potential for altered neuronal excitabilityCardiac effects
06
Interacting drugs
Ketamine
3 more in the full profile.
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