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Target intelligence / Profile preview
Hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3)
- Target
- HCN3
- Molecular classification
- Ion channel, Voltage-gated ion channel, Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channel, Nonselective cation channel
01
Overview
Hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) is a member of the HCN channel family that serves as a nonselective voltage-gated cation channel permeable to sodium and potassium ions, with a preference for potassium ions. It is activated by membrane hyperpolarization and regulated by cyclic nucleotides such as cAMP. HCN3 is expressed in both heart and brain tissues, where it contributes to the generation of rhythmic activity (pacemaker currents) and the regulation of neuronal and cardiac excitability. Dysregulation of HCN channels can play roles in cardiac arrhythmias and certain neurological diseases[1][2][4][5].
- Other names
- HCN3Hyperpolarization-activated cyclic nucleotide-gated K+ channel 3Hyperpolarization-activated ion channel 3Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
02
Mechanism of action
HCN channel blockers (reduce pacemaker current to lower heart rate), Modulators of ion channel activity (alter neuronal and cardiac excitability)
03
Biological functions
Regulation of cardiac and neuronal rhythmicityGeneration of pacemaker currentsPotassium and sodium ion transmembrane transportRegulation of resting membrane potentialDendritic integrationSynaptic transmission
04
Disease associations
Cardiovascular disease (e.g., arrhythmias)Neurodegenerative diseaseOther neurological disorders
05
Safety considerations
Cardiac arrhythmia riskPotential for bradycardiaCentral nervous system effects (e.g. possible impact on neuronal excitability)
06
Interacting drugs
Ivabradine
2 more in the full profile.
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