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Target intelligence / Profile preview
Hyperpolarization activated cyclic nucleotide gated potassium channel 4 (HCN4)
- Target
- HCN4
- Molecular classification
- Ion channel, Potassium channel, Non-selective cation channel
01
Overview
HCN4 is a non-selective cation channel crucial for generating the "funny current" (I_f) in the heart's sinoatrial node, regulating heart rate. It is also expressed in neurons, influencing excitability and plasticity. Mutations in HCN4 are associated with cardiac arrhythmias such as sick sinus syndrome and Brugada syndrome. The channel is regulated by voltage and cyclic nucleotides.
02
Mechanism of action
N/A
03
Biological functions
Pacemaker current generationRegulation of neuronal excitabilityResting potential regulationNeuronal plasticity
04
Disease associations
Sick sinus syndromeBrugada syndromeCardiac arrhythmiaMood disordersNeuropsychiatric conditions
05
Safety considerations
Potential for pro-arrhythmic effects
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