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Target intelligence / Profile preview
Orexin/Hypocretin Receptor Type 2 (OX2R)
- Target
- OX2R
- Molecular classification
- G-protein coupled receptor (GPCR), GPCR 1 family
01
Overview
Orexin/Hypocretin Receptor Type 2 (OX2R) is a G-protein coupled receptor that binds orexin-A and orexin-B. It is primarily expressed in the brain, particularly in wake-promoting regions. OX2R plays a critical role in sleep-wake regulation, feeding behavior, energy homeostasis, reward, and neuroendocrine functions. Disruptions in OX2R signaling are linked to sleep disorders like narcolepsy, and it is a therapeutic target for insomnia, with dual orexin receptor antagonists like suvorexant used in treatment. Selective antagonists are under investigation to improve the therapeutic profile. OX2R is also implicated in neurological diseases such as depression, Alzheimer’s disease, ischemic stroke, and drug addiction.
- Other names
- Ox-2-ROx2-RHypocretin receptor type 2HCRTR2
02
Mechanism of action
Dual orexin receptor antagonist; blocking both OX1R and OX2R.
03
Biological functions
Sleep-wake regulationFeeding behaviorEnergy homeostasisReward & addictionNeuroendocrine & stress responseSignal transduction
04
Disease associations
Sleep disordersNarcolepsyDepressionAlzheimer’s diseaseIschemic strokeDrug addiction
05
Safety considerations
Potential side effects associated with dual orexin receptor antagonism.Therapeutic challenges in selectively targeting OX₂ receptors.
06
Interacting drugs
Suvorexant
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