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Target intelligence / Profile preview
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT)
- Target
- HGXPRT
- Molecular classification
- Enzyme, Phosphoribosyltransferase
01
Overview
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT) is an enzyme crucial for the purine salvage pathway, recycling purines into nucleotide form. It catalyzes the transfer of a ribosyl phosphate group from PRPP to hypoxanthine, guanine, or xanthine, producing IMP, GMP, and XMP. Deficiency leads to Lesch-Nyhan syndrome (complete deficiency) and hyperuricemia with neurological symptoms (partial deficiency). The enzyme is a therapeutic target for managing hyperuricemia and related disorders.
- Other names
- Hypoxanthine-guanine phosphoribosyltransferaseHGPRTHPRT1Guanine phosphoribosyltransferaseXanthine phosphoribosyltransferase
02
Mechanism of action
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate (PRPP) to hypoxanthine, guanine, or xanthine bases, generating IMP, GMP, and XMP respectively. Deficiency leads to increased uric acid production.
03
Biological functions
Purine salvagePurine metabolismGMP salvage pathwayIMP salvage pathwayXMP salvage pathwayNucleotide biosynthesis
04
Disease associations
Lesch-Nyhan syndromeHyperuricemiaGoutKidney stonesNeurological disordersCognitive impairment
05
Safety considerations
Drug interactions (e.g., with immunosuppressants)Risk of myelosuppressionNeurological side effectsHyperuricemia if not managed
06
Interacting drugs
Allopurinol
3 more in the full profile.
07
Biomarkers
Uric acid levelsHGXPRT enzyme activityHypoxanthine levelsGuanine levelsXanthine levels
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