Hypoxia-Inducible Factor (None)

Hypoxia-inducible factors (HIFs) are a family of transcription factors that play a central role in cellular adaptation to low oxygen (hypoxic) conditions. They regulate the expression of genes involved in processes such as angiogenesis, erythropoiesis, metabolism, and cell survival under hypoxic stress. HIFs function as heterodimers composed of an oxygen-sensitive alpha subunit (HIF-1α, HIF-2α, and HIF-3α) and a constitutively expressed beta subunit (ARNT). Under normoxia, the alpha subunit is hydroxylated, leading to its degradation. Under hypoxia, hydroxylation is inhibited, the alpha subunit stabilizes, dimerizes with the beta subunit, and activates transcription of target genes.

Other names

HIFHIF-1HIF-1alphaHIF-2alphaHIF-3alphaARNTHIF-1betaAryl Hydrocarbon Receptor Nuclear Translocator

Inhibition of HIF prolyl hydroxylation, disruption of HIF-VHL interaction, inhibition of HIF transcriptional activity