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Target intelligence / Profile preview
Hypoxia Inducible Factor 1 (HIF-1)
- Target
- HIF-1
- Molecular classification
- Transcription factor, bHLH-PAS protein
01
Overview
Hypoxia Inducible Factor 1 (HIF-1) is a heterodimeric transcription factor that plays a central role in cellular adaptation to low oxygen (hypoxic) conditions. It regulates the expression of numerous genes involved in oxygen homeostasis, angiogenesis, metabolism, and cell survival. HIF-1 is composed of an oxygen-sensitive alpha subunit and a constitutively expressed beta subunit. Under hypoxia, the alpha subunit is stabilized and translocates to the nucleus to activate transcription of target genes. It is an important drug target for cancer therapy.
- Other names
- HIF1HIF-1alpha/beta heterodimer
02
Mechanism of action
Inhibition of HIF-1alpha subunit stabilization or HIF-1 transcriptional activity.
03
Biological functions
Oxygen homeostasisAngiogenesisMetabolismCell survivalTranscriptional regulation
04
Disease associations
CancerIschemiaInflammation
05
Safety considerations
Potential for off-target effects due to broad role in cellular processesRisk of disrupting normal oxygen homeostasisPotential for promoting tumor progression in certain contexts
06
Interacting drugs
Dimethyloxalylglycine
3 more in the full profile.
07
Biomarkers
HIF-1alpha expression levels in tumor tissue
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