Hypoxia-inducible factor 1-alpha (HIF-1α)

Hypoxia-inducible factor 1-alpha (HIF-1α) is a subunit of the heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1), encoded by the HIF1A gene. It is considered the master regulator of cellular and developmental responses to hypoxia, or low oxygen conditions. HIF-1α plays a central role in regulating genes involved in angiogenesis, energy metabolism, cell survival, tumor invasion, and vascularization.

Other names

HIF1A

Currently under research. Several compounds are being developed to inhibit HIF-1α or its downstream targets, aiming to disrupt the pathways that promote tumor growth, angiogenesis, and metastasis. Inhibition typically involves destabilizing HIF-1α, interfering with its dimerization with ARNT/HIF-1β, or blocking its ability to bind to hypoxia-responsive elements (HREs).