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Target intelligence / Profile preview
Hypoxia-inducible factor 1 alpha subunit (HIF1A)
- Target
- HIF1A
- Molecular classification
- Transcription factor, Basic helix-loop-helix PAS domain-containing protein
01
Overview
HIF1A encodes the alpha subunit of hypoxia-inducible factor 1 (HIF-1), a heterodimeric transcription factor that is the master regulator of cellular and developmental responses to low oxygen (hypoxic) conditions. Under hypoxic conditions, HIF-1α stabilizes, translocates to the nucleus, dimerizes with ARNT (HIF-1β), and binds DNA at hypoxia response elements to activate transcription of genes involved in energy metabolism, angiogenesis, apoptosis, oxygen delivery and metabolic adaptation. Plays essential roles in embryonic vascularization, tumor angiogenesis, ischemic disease pathophysiology, placental development during gestation, and neuronal mitochondrial transport under hypoxia.
- Other names
- HIF-1αHIFA
02
Biological functions
Energy metabolismAngiogenesisApoptosisOxygen deliveryMetabolic adaptationRegulation of gene expression
03
Disease associations
CancerRetinal ischemiaMultiple enchondromatosis/Ollier disease typeCancer metastasis
04
Safety considerations
Overexpression or abnormal activation in cancer
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