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Target intelligence / Profile preview
Hypoxia-inducible factor-prolyl hydroxylase (PHD)
- Target
- PHD
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
Hypoxia-inducible factor-prolyl hydroxylases (HIF-PHDs) are a family of iron- and 2-oxoglutarate-dependent enzymes that play a central role in cellular oxygen sensing. They regulate the stability of hypoxia-inducible factors (HIFs), which are transcription factors critical for the cellular response to low oxygen levels (hypoxia). PHD2 is considered the principal oxygen sensor among these isoforms.
- Other names
- HIF-PHDProlyl hydroxylase domain proteinHIF prolyl-hydroxylaseHypoxia-inducible factor-proline dioxygenaseEGLN1EGLN2EGLN3
02
Mechanism of action
Inhibition of HIF-PHD leads to stabilization and activation of hypoxia-inducible factors (HIFs), even under normoxic conditions.
03
Biological functions
Oxygen sensingRegulation of HIF-alpha stabilityRegulation of erythropoiesisRegulation of angiogenesisRegulation of glycolysisIron metabolism
04
Disease associations
AnemiaChronic kidney diseasePolycythemiaIschemic diseasesPulmonary hypertensionCancer progressionCancer metastasis
05
Safety considerations
Potential for erythrocytosisPossible effects on tumor growth and metastasisEffects on angiogenesis require careful consideration
06
Interacting drugs
HIF prolyl-hydroxylase inhibitors
2 more in the full profile.
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