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Target intelligence / Profile preview
Hypoxia-inducible gene RTP801 (RTP801)
- Target
- RTP801
- Molecular classification
- Stress-response protein
01
Overview
Hypoxia-inducible gene RTP801 encodes a highly conserved stress-response protein that integrates environmental cues like hypoxia into intracellular decisions about growth arrest versus survival/apoptosis mainly through negative regulation of the mTOR/Akt axis. Its function varies with cellular context—from protective antioxidant effects during acute proliferation-associated stresses to pro-apoptotic actions driving pathology when chronically elevated post-differentiation or under persistent insult.
- Other names
- REDD1Regulated in Development and DNA Damage Responses 1DDIT4DNA-damage-inducible transcript 4Dig2
02
Mechanism of action
Inhibits mTOR signaling by activating TSC2, negatively regulates Akt signaling.
03
Biological functions
Negative regulation of mTOR signalingRegulation of Akt kinase activityStress responseApoptosis modulationCell growth regulationDifferentiation
04
Disease associations
NeurodegenerationPulmonary injuryEmphysemaCancerLeukemia
05
Safety considerations
Context-dependent effects (pro-apoptotic vs. anti-apoptotic)Potential for off-target effects due to involvement in multiple signaling pathways
06
Interacting drugs
ATRA (all-trans retinoic acid)
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