Hypoxia up-regulated protein 1 (HYOU1)

Hypoxia up-regulated protein 1 (HYOU1) is a large molecular chaperone of the heat shock protein 70 family located in the endoplasmic reticulum. It is induced by hypoxia, ER stress, ischemia, and glucose deprivation, and is pivotal in protein folding, secretion, and the maintenance of ER homeostasis. HYOU1 plays a significant protective role in cell survival under stress by inhibiting apoptosis and supporting the unfolded protein response. High expression of HYOU1 is observed in various cancers and is associated with tumor progression, invasiveness, chemoresistance, and poor clinical outcomes. In addition to its roles in cancer, HYOU1 is implicated in cardiovascular diseases, diabetes, and neurodegenerative disorders. It is being studied as a potential therapeutic target, especially in oncology and diseases linked to ER stress[1][5][3].

Other names

150 kDa oxygen-regulated proteinORP150Glucose-regulated protein 170GRP170GRP-170Heat shock protein family H member 4HSPH4HSP12AIMD59epididymis secretory sperm binding proteinoxygen regulated protein (150 kDa)

Proteasome inhibitors (e.g., MG132) induce HYOU1 expression, which may attenuate apoptosis by modulating ER stress pathways[1]. Experimental small-molecule inhibitors can suppress HYOU1’s chaperone activity, impairing tumor cell growth and viability[6]. Celecoxib up-regulates HYOU1 expression via ER stress signaling[1].