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Hypoxic Cell
- Molecular classification
- Cellular state, Microenvironmental component
01
Overview
A hypoxic cell is a cell experiencing a state of oxygen deprivation (hypoxia). These cells activate adaptive mechanisms primarily through hypoxia-inducible factors (HIFs) to survive under low oxygen conditions. Hypoxic cells play critical roles in diseases like cancer (promoting tumor growth, metastasis, and therapy resistance) and ischemic diseases. While not a direct therapeutic target itself, the pathways activated in hypoxic cells are often targeted for therapeutic intervention.
- Other names
- Oxygen-deprived cellHypoxia-exposed cell
02
Mechanism of action
N/A
03
Biological functions
Adaptation to low oxygenAnaerobic metabolismAngiogenesis stimulationErythropoiesis stimulationSurvival under stress
04
Disease associations
Tumor progressionCancer metastasisTherapy resistance (cancer)Ischemic injuryWound healing
05
Safety considerations
Targeting hypoxia can disrupt normal physiological processes (e.g., wound healing)Potential for off-target effects on normoxic cells adapting to other stresses
06
Interacting drugs
HIF inhibitors
2 more in the full profile.
07
Biomarkers
HIF-1α expressionVEGF levelsGlut1 expressionCA9 expression
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