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Hypoxic Cell Marker
- Molecular classification
- Transcription factor, Enzyme, Transporter, Protein
01
Overview
Hypoxic cell markers are molecules used to identify cells or tissues experiencing hypoxia, a state of reduced oxygen availability. These markers are either endogenous proteins whose expression increases under low oxygen conditions or exogenous compounds that selectively bind to hypoxic cells.
- Other names
- HIF-1αCA IXCA9GLUT1GLUT-IBNIP3ERO1αEF5
02
Biological functions
Cell survivalAngiogenesisMetabolismpH regulationAutophagyGlucose transport
03
Disease associations
Cancer
04
Safety considerations
Non-specific targeting of hypoxic cellsPotential for off-target effects of hypoxia-targeting drugs
05
Biomarkers
HIF-1α expressionCA9 expressionGLUT1 expressionBNIP3 expressionEF5 adducts
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