Cellular hypoxia

Cellular hypoxia is a physiological state in which cells experience insufficient oxygen supply to maintain normal function, causing a broad spectrum of adaptive metabolic, transcriptional, and signaling responses[1][7][9]. These include stabilizing hypoxia-inducible factors (HIFs), shifting metabolism from oxidative phosphorylation to glycolysis, modulating cell proliferation, survival, and inducing angiogenesis, as well as promoting pathophysiological states such as cancer, ischemic injury, and inflammation[8][4][1]. Cellular hypoxia is not a druggable molecule itself but rather a context or condition; therapeutic interest focuses on targeting the hypoxia signaling pathways, especially HIFs and oxygen-sensing enzymes[10][8][1].\n\nKey point: Cellular hypoxia is not a canonical molecular target such as a receptor or enzyme for direct drug action, but refers to a state of oxygen deprivation that triggers specific molecular responses, which can serve as therapeutic targets.

Other names

Hypoxic statetissue hypoxiacellular oxygen deprivationintracellular hypoxiahypoxic microenvironment