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I-Ag7
- Target
- I-Ag7
- Molecular classification
- MHC class II molecule, Receptor
01
Overview
I-Ag7 is a murine MHC class II molecule strongly associated with susceptibility to type 1 diabetes in NOD mice. It presents peptides derived from pancreatic beta cells to CD4+ T cells, initiating autoreactive immune responses. Its unique structural features, particularly polymorphisms in the beta chain (His56/Ser57), alter its peptide binding specificity, favoring peptides with acidic residues at P9 and enhancing its interaction with diabetogenic T cell receptors.
- Other names
- ag7 antigenH2-Abg7
02
Mechanism of action
Modulation of T cell activation through altered peptide presentation
03
Biological functions
Antigen presentationT cell activationImmune response
04
Disease associations
Type 1 diabetesAutoimmunity
05
Safety considerations
Potential for broad immunosuppression if targeted systemicallyRisk of exacerbating other autoimmune conditionsComplex interplay with other MHC molecules
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