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Target intelligence / Profile preview
I-kappa B kinase epsilon (IKK-epsilon)
- Target
- IKK-epsilon
- Molecular classification
- Enzyme, Protein Kinase, Serine/Threonine Kinase, I-kappa-B kinase subfamily
01
Overview
I-kappa B kinase epsilon (IKK-epsilon) is a serine/threonine protein kinase that plays a central role in regulating immune and inflammatory responses, particularly those triggered by viral infections. It activates type I interferon (IFN), NF-kappa-B, and STAT signaling pathways in response to viral infection. It is a potential therapeutic target for inflammatory diseases and cancer.
- Other names
- IKKEIKKεInducible IkB KinaseInducible IkB Kinase EpsilonInhibitor of nuclear factor kappa-B kinase subunit epsilonKIAA0151
02
Mechanism of action
Kinase inhibition
03
Biological functions
Immune responseInflammationAntiviral signalingNF-kappa-B signalingType I interferon signalingSTAT signalingCell survivalMetabolic regulation
04
Disease associations
Inflammatory diseasesCancerViral infectionsObesityInsulin resistance
05
Safety considerations
Potential for off-target effects due to kinase family similaritiesLong-term effects of modulating inflammatory pathways
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