IDH1 antisense RNA 1 (IDH1-AS1)

IDH1 antisense RNA 1 (IDH1-AS1) is a cytoplasmic long non-coding RNA transcribed in proximity and antisense to the IDH1 gene. Unlike other antisense RNAs that regulate gene expression, IDH1-AS1 does not alter IDH1 mRNA or protein levels, but physically interacts with wild-type IDH1 enzyme and enhances its enzymatic activity by promoting homodimerization[4][2]. This interaction selectively increases the conversion of isocitrate to α-ketoglutarate and NADPH, thereby reducing cellular reactive oxygen species (ROS)[4]. IDH1-AS1 also links the metabolic and transcriptional activities of c-Myc and HIF1α, and participates in oncogenic processes, including sustaining the Warburg effect and regulating autophagy in cancer cells[4][2][6]. It is implicated in the development and progression of cancers such as glioma and prostate cancer, serving as a potential biomarker and therapeutic target[5][4][2][6]. However, there are no specific clinical drugs that directly target IDH1-AS1 at present.

Other names

IDH1-AS1IDH1 antisense RNA 1 (non-protein coding)IDH1 antisense RNA 1lncRNA IDH1-AS1

Not applicable for drugs directly targeting IDH1-AS1; for IDH1 pathway inhibition, mechanisms include modulation of IDH1 enzyme activity, alteration of metabolite production (α-ketoglutarate, NADPH), and downstream effects on gene expression and cellular metabolism