IDH1 pseudogene 1 (IDH1P1)

IDH1 pseudogene 1 (IDH1P1) is a non-functional gene with sequence similarity to the IDH1 enzyme gene. Unlike IDH1, which encodes a cytosolic and peroxisomal enzyme involved in NADPH generation and implicated in cancer biology[1][7][8], IDH1P1 does not encode an active protein and is not involved in metabolic pathways or disease. It is sometimes mistakenly listed or searched as a biological or therapeutic target, but it should not be considered for drug development, biomarker analysis, or molecular classification. Clarification: The true target of interest in cancer and metabolic research is isocitrate dehydrogenase 1 (IDH1), which is an enzyme involved in the citric acid cycle and is frequently mutated in diffuse gliomas and other tumors[1][5][7]. IDH1P1 should not be confused with IDH1. If your intent is to obtain structured information on the actual enzyme target, search for "Isocitrate dehydrogenase 1 (IDH1)" instead.