Drug pipeline
Explore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Iduronate 2-sulfatase (I2S)
- Target
- I2S
- Molecular classification
- Enzyme, Sulfatase
01
Overview
Iduronate 2-sulfatase (I2S) is a lysosomal enzyme essential for the degradation of glycosaminoglycans (GAGs), specifically heparan sulfate and dermatan sulfate. Deficiency or dysfunction of I2S due to mutations in the IDS gene leads to mucopolysaccharidosis type II (MPS II), also known as Hunter syndrome.
- Other names
- L-idurono sulfate sulfataseiduronide-2-sulfate sulfatasesulfoiduronate sulfohydrolaseL-iduronosulfatase
02
Mechanism of action
Hydrolyzes C-2 sulfates from L-iduronic acid residues in heparan sulfate and dermatan sulfate.
03
Biological functions
Glycosaminoglycan catabolismLysosomal degradation pathways
04
Disease associations
Mucopolysaccharidosis type IIHunter syndrome
Beyond the preview
Go deeper on Iduronate 2-sulfatase (I2S).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Follow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Compare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Investigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Explore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Connect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Iduronate 2-sulfatase (I2S).