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Target intelligence / Profile preview
IgE Fc Receptor Alpha Subunit (FCER1A)
- Target
- FCER1A
- Molecular classification
- Receptor, IgE Receptor
01
Overview
The IgE Fc receptor alpha-subunit (FCER1A) is the alpha chain of the high-affinity IgE receptor complex (FcεRI). This receptor plays a central role in allergic and inflammatory responses by mediating the effects of IgE antibodies. Upon allergen exposure, allergen crosslinks IgE bound to FCER1A, triggering cell activation and release of inflammatory mediators, driving clinical symptoms seen in allergic reactions. It is expressed primarily on mast cells and basophils, and dysregulation contributes to various allergic diseases.
- Other names
- FcεRIαFCE1AHigh affinity immunoglobulin epsilon receptor subunit alphaFceR1a
02
Mechanism of action
Modulation of IgE binding and downstream signaling pathways
03
Biological functions
Allergic response initiationInflammatory mediator releaseLeukotriene biosynthesisRegulation of immune cell activationIgE binding
04
Disease associations
AsthmaAtopic dermatitisFood allergiesAnaphylaxisAllergic diseasesHypereosinophilic syndrome
05
Safety considerations
Potential for immune suppressionRisk of off-target effects on other immune cells
06
Biomarkers
Allergy severity
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