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IgE-Mediated Hypersensitivity Pathway
- Molecular classification
- Signaling Pathway, Immune Pathway
01
Overview
The IgE-mediated hypersensitivity pathway is an immune response characterized by the production of IgE antibodies against specific allergens. This pathway is central to allergic diseases and anaphylaxis. It involves sensitization (IgE production and binding to mast cells/basophils) and subsequent re-exposure, which triggers mast cell/basophil degranulation and release of inflammatory mediators, leading to allergic symptoms.
- Other names
- Type I HypersensitivityImmediate HypersensitivityAllergic Reaction Pathway
02
Mechanism of action
Multiple, depending on the drug. Examples include: Histamine receptor blockade, reduction of inflammation, IgE neutralization, inhibition of leukotriene synthesis/action, stabilization of mast cell membranes.
03
Biological functions
Immune responseInflammationAllergic reactionDefense against parasites (minor role)
04
Disease associations
Allergic rhinitisAsthmaAtopic dermatitisFood allergyAnaphylaxisUrticaria
05
Safety considerations
Anaphylaxis (severe allergic reaction)Side effects of medications used to treat allergic reactions (e.g., drowsiness with antihistamines, immunosuppression with corticosteroids)
06
Interacting drugs
Antihistamines
5 more in the full profile.
07
Biomarkers
Serum IgE levelsSpecific IgE antibodies (allergen-specific IgE)Skin prick test results
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