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Immunoglobulin E Receptor (IgE Receptor)

Target: IgE Receptor
Molecular classification: Receptor, Type I transmembrane protein (FcεRI), Type II transmembrane protein (CD23)

Overview

The immunoglobulin E receptor (IgE Receptor) refers to cell-surface proteins that specifically bind to the constant region of Immunoglobulin E (IgE) antibodies. These receptors are central to the allergic response and play a key role in immune defense against parasites. The high-affinity receptor (FcεRI) triggers degranulation and release of mediators upon allergen exposure, while the low-affinity receptor (CD23/FcεRII) regulates serum IgE levels and facilitates allergen presentation.

Other names: FcεRICD23FcεRIIHigh-affinity IgE receptorLow-affinity IgE receptor

Mechanism of action

Monoclonal antibodies that bind free human IgE, preventing interaction with FcεRI/CD23.

Biological functions

Mediates allergic responsesDefense against parasitesIgE regulationAntigen presentationImmune response

Disease associations

Allergic rhinitisAsthmaAtopic dermatitisFood allergiesAnaphylaxis

Interacting drugs

Omalizumab

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