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Target intelligence / Profile preview
IGF-like family receptor 1 (IGFLR1)
- Target
- IGFLR1
- Molecular classification
- Receptor, Transmembrane protein, Tumor necrosis factor receptor family-like protein
01
Overview
IGF-like family receptor 1 (IGFLR1) is a structurally novel cell-surface receptor resembling members of the TNFR superfamily, encoded on chromosome 19. Its ligand is IGF-like family member 1 (IGFL1). IGFLR1 is expressed broadly, but especially in lymph nodes, spleen, kidney, and on T cells. Functionally, IGFLR1 binds IGFL1 with high affinity and participates in regulation of T cell responses, with elevated expression promoting inflammatory infiltration and activation. Recent evidence links IGFLR1 to pathogenesis and prognosis in several cancers, such as pancreatic ductal adenocarcinoma and clear cell renal cell carcinoma. High IGFLR1 expression is associated with poor survival in some tumor types, and its presence marks aggressive T cell phenotypes. As a novel therapeutic target, IGFLR1 currently lacks direct pharmacological modulators, but research is ongoing into its role in immune regulation and cancer biology.
- Other names
- IGFLR1TMEM149U2AF1L4FLJ22573Transmembrane protein 149U2 small nuclear RNA auxiliary factor 1-like 4
02
Biological functions
Signal transductionRegulation of T cell responseInflammatory cell infiltration and activationPotential regulation of growth and metabolism (by analogy to IGF family)
03
Disease associations
Cancer (pancreatic ductal adenocarcinoma, clear cell renal cell carcinoma, possibly other cancers)Inflammation and immune response (regulation of T cell activation and infiltration; possible roles in allergic/psoriatic skin diseases)
04
Biomarkers
High expression of IGFLR1 may serve as a prognostic biomarker in cancer, notably clear cell renal cell carcinoma; may help in diagnosis, treatment, and prognosis of cancers
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