IgLON family member 5 (IGLON5)

IgLON family member 5 is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein of the immunoglobulin superfamily, found primarily in neurons and oligodendrocytes but also expressed in skeletal muscle and some non-neural tissues[1][2][3][4]. Like other IgLONs, it forms homophilic or heterophilic complexes and is essential for cell adhesion, neuronal migration, axon guidance, and muscle cell differentiation and regeneration[1][2][3]. Pathogenic autoantibodies targeting IgLON5 underlie anti-IgLON5 disease, a rare neurodegenerative tauopathy characterized by sleep disorders and neuronal cytoskeletal pathology, suggesting a crucial, multifaceted role in nervous system and muscle integrity[3][4]. There are currently no approved drugs targeting IgLON5 directly; however, IgLON5 antibodies serve as important diagnostic biomarkers for the corresponding autoimmune syndrome[3][4][1].

Other names

IGLON5LOC402665Ig-like domain-containing protein ENSP00000270642hCG1651476igLON5