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Target intelligence / Profile preview
IkappaB kinase (IKK)
- Target
- IKK
- Molecular classification
- Enzyme, Serine/threonine protein kinase, Protein complex
01
Overview
IkappaB kinase (IKK) is a critical enzyme complex involved in the regulation of immune and inflammatory responses, primarily through its central role in activating the NF-κB signaling pathway. It is a serine/threonine protein kinase composed of IKKα, IKKβ, and NEMO subunits. Upon stimulation by pro-inflammatory signals, IKK phosphorylates IkappaBs, leading to their degradation and the subsequent activation of NF-κB transcription factors.
- Other names
- IkappaB kinase complexIKK complex
02
Mechanism of action
Inhibition of IKK complex activity, leading to reduced NF-κB activation and downstream effects on inflammation, cell survival, and proliferation.
03
Biological functions
Signal transductionImmune responseInflammationCell survivalCell proliferationActivation of NF-κB signaling pathway
04
Disease associations
Chronic inflammatory diseasesCancerNeurodegenerative disease
05
Safety considerations
Potential for immunosuppressionOff-target effects of inhibitors
06
Interacting drugs
SAR113945
2 more in the full profile.
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