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Target intelligence / Profile preview
IKAROS family zinc finger 1
- Molecular classification
- Transcription factor, Zinc finger protein
01
Overview
IKZF1, also known as Ikaros, is a zinc finger transcription factor crucial for lymphoid cell development and hematopoiesis. It regulates gene expression through chromatin remodeling and interacts with co-repressors and co-activators. IKZF1 is frequently deleted or mutated in B-cell precursor acute lymphoblastic leukemia (B-ALL), leading to poor prognosis. While direct targeting of IKZF1 is not currently possible, downstream pathways affected by its loss are being explored for therapeutic intervention.
- Other names
- Ikaros
02
Mechanism of action
Indirectly targetable via downstream pathways like JAK/STAT signaling or PI3K pathway. Casein kinase 2 inhibitors can restore some IKZF1 function.
03
Biological functions
Lymphoid differentiationRegulation of hematopoiesisTumor suppressionRegulation of gene expressionChromatin remodeling
04
Disease associations
Acute lymphoblastic leukemia (ALL)Immunodeficiency syndromes
05
Safety considerations
Loss of IKZF1 function leads to treatment resistance in ALL.Therapeutic targeting of downstream pathways may have off-target effects.
06
Biomarkers
IKZF1 deletions/mutations in B-ALL (prognostic biomarker)SNPs near IKZF1 (susceptibility to childhood ALL and type 1 diabetes)
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