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Target intelligence / Profile preview
IKAROS family zinc finger 3 (IKZF3)
- Target
- IKZF3
- Molecular classification
- Transcription factor, Zinc finger protein
01
Overview
IKZF3 encodes a hematopoietic-specific transcription factor belonging to the Ikaros family of zinc-finger proteins. It plays a crucial role in regulating B lymphocyte proliferation, differentiation, and maturation. The protein is also involved in chromatin remodeling and regulates gene expression in B lymphocytes through complex dimerization patterns. Dysregulation or mutation of IKZF3 has been associated with hematological malignancies, primary immunodeficiency disorders, and autoimmune diseases.
- Other names
- Zinc finger protein AiolosAiolos
02
Mechanism of action
Transcriptional repression or activation depending on dimerization partners and genomic context. Influences lymphocyte development and function.
03
Biological functions
Regulation of B-cell proliferationB-cell differentiationB-cell maturationChromatin remodelingRegulation of gene expressionImmune responseActivation of B cell receptor signaling pathwayT cell receptor signaling pathwayLeukocyte migrationAntigen processing/presentationMaintaining immune homeostasisSuppressing tumor growth
04
Disease associations
Hematological malignanciesLeukemiaPrimary immunodeficiency disordersAutoimmune diseasesImmune thrombocytopeniaSystemic lupus erythematosusRheumatoid arthritis
05
Safety considerations
Dysregulation or mutation associated with various diseasesPotential for off-target effects due to DNA binding
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