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Target intelligence / Profile preview
Ikaros Family Zinc Finger Protein 1 (IKZF1)
- Target
- IKZF1
- Molecular classification
- Transcription factor, Zinc finger protein
01
Overview
Ikaros family zinc finger protein 1 is an essential transcription factor governing lymphoid development through direct control over gene expression programs required for immune cell differentiation. Its structural integrity—particularly its six-zinc-finger motif—is vital for both DNA binding specificity/functionality and dimerization capacity. Loss-of-function alterations drive susceptibility/progression of acute lymphoblastic leukemia while germline defects cause primary immunodeficiencies. As such, it serves both as a biological master regulator within hematopoiesis/immunity pathways and an important clinical biomarker/prognostic indicator across several blood disorders.
- Other names
- IkarosLYF1
02
Mechanism of action
Not applicable (transcription factor, not directly druggable with conventional small molecules)
03
Biological functions
Lymphocyte differentiationHematopoiesisTranscriptional regulationB-cell developmentChromatin remodeling
04
Disease associations
LeukemiaAcute lymphoblastic leukemia (ALL)ImmunodeficiencyCancer
05
Safety considerations
Altered IKZF1 function can lead to immune dysregulation and increased risk of leukemia
06
Biomarkers
IKZF1 deletions/mutations in ALL
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