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Target intelligence / Profile preview
Zinc finger protein Aiolos (IKZF3)
- Target
- IKZF3
- Molecular classification
- Transcription factor, Zinc-finger protein, Ikaros family protein
01
Overview
Zinc finger protein Aiolos (IKZF3) is a hematopoietic-specific transcription factor belonging to the Ikaros family. It plays a critical role in B lymphocyte development, differentiation, and maturation. Aiolos regulates gene expression through chromatin remodeling and interacts with other Ikaros family members. Disruption or mutation of IKZF3 is associated with hematological malignancies, immunodeficiency, and autoimmune diseases. It has also been identified as a prognostic biomarker for certain cancers.
- Other names
- Ikaros family zinc finger protein 3ZNFN1A3
02
Mechanism of action
Regulation of transcription through DNA binding and dimerization with other Ikaros family members, influencing chromatin remodeling and gene expression.
03
Biological functions
Regulation of B lymphocyte proliferationRegulation of B lymphocyte differentiationRegulation of B lymphocyte maturationRegulation of gene expressionChromatin remodelingLymphocyte developmentB cell receptor signalingT cell receptor signalingLeukocyte migrationAntigen processing/presentationImmune regulation
04
Disease associations
Hematological malignanciesLeukemiaLymphomaPrimary immunodeficiency syndromesAutoimmune diseasesSystemic lupus erythematosusRheumatoid arthritisCancer
05
Safety considerations
Dysregulation can contribute to primary immunodeficiency syndromes.Implicated in autoimmune diseases due to its role balancing autoimmunity versus immune suppression.
06
Biomarkers
Prognostic biomarker for head and neck squamous cell carcinoma
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