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Target intelligence / Profile preview
Ikaros family zinc finger protein 5 (IKZF5)
- Target
- IKZF5
- Molecular classification
- Transcription factor, Zinc finger protein
01
Overview
Ikaros family zinc finger protein 5 (IKZF5, Pegasus) is a transcriptional repressor and DNA-binding zinc finger protein that plays a regulatory role in gene expression, particularly through binding to the consensus DNA sequence 5'GNNTGTNG-3'. It is involved in megakaryocyte differentiation and implicated in lymphoid cell development, underscoring its importance in hematopoiesis and immune regulation. IKZF5 interacts with chromatin remodeling complexes and other transcriptional machinery to modulate target gene transcription. Defects or mutations in IKZF5 have been associated with thrombocytopenia and may contribute to disorders involving immune cell dysregulation[1][2][5].
- Other names
- Zinc finger protein PegasusIKZF5ZNFN1A5PegasusFLJ22973THC7Zinc finger transcription factor PegasusZinc finger protein, subfamily 1A, 5 (Pegasus)
02
Mechanism of action
Not reported for IKZF5 directly. For Ikaros family members in general, mechanisms include modulation of transcriptional activity and immune cell differentiation.
03
Biological functions
Transcriptional repressionDNA binding to target gene promotersRegulation of gene expression via chromatin remodeling and transcriptional complexesMegakaryocyte differentiationRegulation of lymphoid cell development (especially B, T, and NK cells)
04
Disease associations
Thrombocytopenia 7Autosomal thrombocytopenia with normal plateletsRegulation of immune cell differentiation, potentially relevant to immune disorders and hematopoietic dysfunction
05
Safety considerations
Not specifically established for IKZF5 as a drug target. General concerns for transcription factors include risks of off-target gene regulation and broad effects on cell differentiation.
06
Interacting drugs
No drugs directly reported to interact with IKZF5 or its protein product in current sources. Most drug targeting in the Ikaros family is directed toward other members (e.g., IKZF1/IKZF3), not IKZF5.
07
Biomarkers
Not established for IKZF5 specifically; other Ikaros family members are studied as immune system biomarkers.
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