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Target intelligence / Profile preview
Ikaros Transcription Factor (IKZF1)
- Target
- IKZF1
- Molecular classification
- Transcription factor, Zinc finger protein, DNA-binding protein
01
Overview
Ikaros (IKZF1) is a zinc-finger DNA-binding protein and transcription factor crucial for hematopoiesis and immune cell development, especially in B cells and CD4+ T cells. It functions as both a transcriptional activator and repressor through cofactor interactions and chromatin modification. Dysfunction is linked to leukemia, particularly B-cell ALL, and other immune disorders. It regulates the expression of key genes involved in immune cell differentiation and cytokine production.
- Other names
- Ikaros family zinc finger protein 1
02
Mechanism of action
Transcriptional activation or repression via co-factor interactions and chromatin modification (e.g., recruitment of histone deacetylase complexes)
03
Biological functions
Hematopoiesis regulationImmune cell developmentTranscriptional activatorTranscriptional repressorChromatin remodelingVDJ recombinationClass switch recombinationRegulation of cytokine expressionT cell differentiation
04
Disease associations
Cancer (B-cell ALL)Chronic lymphocytic leukemiaAutoimmunity (Type I diabetes)Immune dysregulation
05
Safety considerations
Potential for broad immune dysregulation due to its role in hematopoiesis and T cell differentiation.Dysregulation can contribute to leukemia development.
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