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Solute carrier family 10 member 2
- Molecular classification
- Transporter, Solute Carrier, SLC10 Family Member
01
Overview
Solute carrier family 10 member 2 (SLC10A2), also known as the apical sodium-dependent bile acid transporter (ASBT) or ileal bile acid transporter (IBAT), is a sodium/bile acid cotransporter primarily expressed in the ileum. It mediates the reabsorption of bile acids from the small intestine, playing a crucial role in enterohepatic circulation, cholesterol homeostasis, and lipid digestion. SLC10A2 is a therapeutic target for gastrointestinal disorders and metabolic diseases, with inhibitors under development to modulate bile acid recycling.
- Other names
- ASBTApical Sodium-dependent Bile Acid TransporterIBATIleal Bile Acid TransporterISBTNTCP2PBAMPBAM1
02
Mechanism of action
Inhibition of ASBT/IBAT, modulating bile acid recycling
03
Biological functions
Bile acid transportEnterohepatic circulationCholesterol homeostasisLipid digestionSodium-dependent transport
04
Disease associations
ConstipationIrritable bowel syndromeNonalcoholic steatohepatitis (NASH)Cholesterol metabolism disorders
05
Safety considerations
Potential alterations in cholesterol metabolism due to impaired enterohepatic circulationGastrointestinal side effects from bile acid malabsorption
06
Interacting drugs
Elobixibat
1 more in the full profile.
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