Imatinib-upregulated long non-coding RNA 1 (lncRNA-IUR1)

Imatinib-upregulated long non-coding RNA 1 (lncRNA-IUR1, also known as LOC100129203 or LNCRNA-IUR) is a long non-coding RNA located on human chromosome 11 between the purinergic receptor P2Y2 and FCH and double SH3 domains 2 genes. It is classified as a non-coding RNA, confirmed to lack protein-coding potential, and is found in both cytoplasm and nucleus of leukemic cells. lncRNA-IUR1 is expressed at very low levels in Bcr-Abl-positive chronic myeloid leukemia cells but is strongly upregulated following treatment with imatinib. Functionally, lncRNA-IUR1 acts as a negative regulator of Bcr-Abl-induced leukemia by suppressing STAT5-mediated GATA3 expression, reducing leukemic cell survival, and promoting apoptosis. Loss of lncRNA-IUR1 expression facilitates tumor cell survival and leukemia progression in vitro and in vivo, suggesting its role as a tumor suppressor lncRNA in the context of hematological malignancies. While not a classic therapeutic target such as a receptor or enzyme, lncRNA-IUR1 has potential utility as a molecular biomarker for imatinib response, and manipulating its expression could represent a novel therapeutic strategy for CML and related disorders.

Other names

lncRNA-IUR1lncRNA imatinib upregulatedLOC100129203LNCRNA-IUR

Not a drug target; its upregulation by imatinib negatively regulates leukemia cell survival via suppression of the STAT5/GATA3 pathway