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Target intelligence / Profile preview
Immediate Early 1 protein (Cytomegalovirus) (IE1)
- Target
- IE1
- Molecular classification
- Transcription factor, Viral protein
01
Overview
The Immediate Early 1 (IE1) protein of human cytomegalovirus (HCMV) is one of the first viral proteins expressed upon infection or reactivation. It acts as a transcriptional regulator, initiating viral gene expression and modulating host immune responses, including inhibiting apoptosis and modifying PML nuclear bodies. IE1 is a key target for diagnostic assays and T-cell response studies, particularly in immunocompromised patients. Detection of IE1-specific immune responses indicates active CMV replication.
- Other names
- IE72IE1-72kDaCMV major immediate early antigen
02
Mechanism of action
N/A
03
Biological functions
Transcriptional regulationInhibition of apoptosisModulation of innate/intrinsic immunityViral replication
04
Disease associations
InfectionCytomegalovirus infectionImmunodeficiency
05
Safety considerations
Potential for off-target effects when targeting viral proteinsDevelopment of drug resistance
06
Biomarkers
Detection of IE1-specific antibodiesDetection of IE1-specific T-cell responses
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