Immune and Central Nervous System Cells

The category "Immune and Central Nervous System Cells" encompasses a spectrum of **immune cell types present within the CNS**, including microglia (the primary innate immune cells of the brain), astrocytes, oligodendrocytes, meningeal macrophages, perivascular macrophages, as well as infiltrating lymphocytes such as T and B cells[1][3][5][6]. These cells play varied roles in CNS homeostasis, immune surveillance, inflammatory responses, synaptic modulation, and neurodevelopment. Dysfunction or dysregulation of CNS immune cells is involved in the pathogenesis of a broad range of neurological diseases including multiple sclerosis, neurodegenerative disorders (e.g., Alzheimer's, Parkinson's), CNS infections, and CNS tumors[2][3][7]. Because this group is heterogeneous and not a single molecular entity, it is not an appropriate target designation for pharmacological intervention.

Other names

CNS immune cellsCNS glial cellsBrain-resident immune cellsNeuroimmune cells