Immune and hematopoietic cells

Immune and hematopoietic cells encompass the diverse array of cells responsible for blood formation and immune defense, all originating from multipotent hematopoietic stem cells in the bone marrow (StatPearls, 2023). This category includes erythrocytes for oxygen transport, platelets for coagulation, and various leukocytes—such as lymphocytes, granulocytes, and monocytes—that mediate innate and adaptive immunity (Janeway's Immunobiology, 2017). While these cells are central to the pathophysiology of numerous conditions, including hematologic malignancies, autoimmune disorders, and inflammatory diseases, the term "Immune and hematopoietic cells" does not refer to a single molecular target. In a drug discovery context, this entry is considered incorrect or too broad because it lacks a specific protein, enzyme, or receptor identity. Instead, therapeutic agents are designed to interact with specific molecular components within these cells, such as surface antigens (e.g., CD20), cytokines, or intracellular signaling molecules (e.g., Bruton's tyrosine kinase), to modulate their activity or survival (NCI, 2023).

Other names

Hematopoietic systemImmune system cellsBlood cellsLeukocytes and precursorsHematopoietic lineage

Not applicable as this refers to a broad cell population rather than a specific molecular target.