Immune and neural cells via cell-cell contact molecules and soluble factors

The term "Immune and neural cells via cell-cell contact molecules and soluble factors" refers to the neuro-immune axis, a bidirectional communication system between the nervous and immune systems (Nature Reviews Immunology, 2020). This interaction occurs through direct cell-cell contact using molecules like cell adhesion molecules (CAMs) and through soluble factors such as cytokines, chemokines, and neurotransmitters (PubMed, PMC5517315). These pathways are critical for maintaining homeostasis, responding to injury, and regulating synaptic plasticity (Science, 2017). Dysregulation of this crosstalk is implicated in neurodegenerative diseases like Alzheimer's and autoimmune conditions like Multiple Sclerosis (NIH, 2021). Because this entry describes a broad physiological interface rather than a single protein, it is not a discrete therapeutic target. Instead, it represents a complex network where specific components, such as TNF-alpha or IL-6 receptors, are targeted by drugs like infliximab or tocilizumab to modulate the overall system (StatPearls, 2023).

Other names

Neuro-immune axisNeuro-immune crosstalkNeuro-immune interactionNeuro-immune signaling

Not applicable as this represents a complex biological interface rather than a single molecular target.