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Target intelligence / Profile preview
Immune Cell Depletion via Targeted Radiotherapy (N/A)
- Target
- N/A
- Molecular classification
- Radiation Therapy, Immunomodulation, Cell Death Induction
01
Overview
Immune cell depletion via targeted radiotherapy involves the use of ionizing radiation to selectively reduce or eliminate specific immune cell populations, particularly lymphocytes, within tissues including tumors. This modulation of immune responses is employed for therapeutic benefit, either alone or in combination with immunotherapies. The outcome (immunostimulatory versus immunosuppressive) depends on factors like dose, fractionation, and timing.
- Other names
- Targeted RadiotherapyImmune Modulation by RadiationRadiation-induced Immune Cell Depletion
02
Mechanism of action
Ionizing radiation induces DNA damage and apoptosis in radiosensitive immune cells, leading to their depletion. Can modulate the tumor microenvironment and immune response.
03
Biological functions
Immune cell depletionTumor microenvironment modulationImmunosuppressionImmunostimulation
04
Disease associations
CancerInflammationAutoimmune Diseases
05
Safety considerations
LymphopeniaImmunosuppressionSecondary malignanciesRadiation-induced toxicityPotential for rebound immunosuppression or resistance
06
Interacting drugs
Checkpoint Inhibitors (e.g., anti-PD-1, anti-PD-L1, anti-CTLA-4)
2 more in the full profile.
07
Biomarkers
Lymphocyte countTumor-infiltrating lymphocytes (TILs)PD-L1 expressionCytokine levels (e.g., IFN-gamma, TNF-alpha)MDSC levelsTreg levels
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