Immune cell metabolic pathways

Immune cell metabolic pathways" describes the core metabolic circuits—including glycolysis, tricarboxylic acid (TCA) cycle, pentose phosphate pathway, fatty acid oxidation and synthesis, and amino acid metabolism—that sustain the energy, biosynthetic, and regulatory needs of different immune cell types[1][7]. These pathways are dynamically regulated during immune activation, differentiation, and effector function, a phenomenon termed immunometabolic reprogramming[1][2][4]. The metabolic state of immune cells shapes their function (e.g., glycolysis is upregulated in activated T cells and M1 macrophages), influences immune fate and tolerance, and plays key roles in disease states such as cancer, infection, and autoimmunity[1][5][6]. Therapeutic exploitation of immune cell metabolism focuses on specific pathway regulators (such as mTOR, AMPK, IDO1, etc.), not on "immune cell metabolic pathways" per se. This entry likely stems from an attempt to reference the increasingly important field of immunometabolism, but should not be treated as a druggable target or a standard molecule/receptor for structured data purposes.

Other names

immunometabolismimmune metabolismmetabolic reprogramming of immune cellsimmune cell metabolism