Immune cells and progenitor cells in the tissue microenvironment

The phrase "immune cells and progenitor cells in the tissue microenvironment" refers to the various immune (e.g., macrophages, neutrophils, lymphocytes) and progenitor or stem cells (e.g., mesenchymal stem cells, hematopoietic progenitor cells) that reside within, or are recruited to, tissue niches[3][4][5][7]. These cell populations interact through cell-cell contact and soluble mediators with each other, as well as with stromal and parenchymal cells, shaping local biological processes such as inflammation, regeneration, and disease progression. While vital for tissue homeostasis and repair, their roles are multifaceted and context-dependent; for example, immune cells may either promote or inhibit tumor progression depending on environmental cues[5][8]. As a group label, this term is not used for specific targeting by drugs or as a molecular biomarker, but rather as a high-level descriptor of functionally distinct but interacting cell populations within tissues.

Other names

Immune cell populationsprogenitor cell populationstissue-resident immune cellsstem/progenitor cells