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Immune Complexes (IC)

Target: IC
Molecular classification: Complex, Molecular Aggregate

Overview

Immune complexes, also known as antigen-antibody complexes or antigen-bound antibodies, are molecular structures formed when antibodies bind to their specific target antigens (which may be parts of pathogens or other foreign substances). These complexes play a central role in the immune response by neutralizing pathogens and facilitating their removal from the body. However, excessive or persistent formation/deposition of immune complexes can lead to tissue damage and inflammation, contributing to various autoimmune diseases.

Other names: Antigen-Antibody ComplexesAntigen-Bound Antibodies

Mechanism of action

N/A

Biological functions

NeutralizationOpsonizationAgglutinationPrecipitationComplement ActivationPathogen Clearance

Disease associations

InflammationAutoimmunityVasculitisGlomerulonephritisRheumatoid ArthritisSystemic Lupus Erythematosus (SLE)SclerodermaSjögren's SyndromeImmune Complex-Mediated Hypersensitivity (Type III)

Safety considerations

Tissue Damage due to DepositionInflammationAutoimmunity

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