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Target intelligence / Profile preview
Immune Effector Cells
- Molecular classification
- T Cells, B Cells, Natural Killer (NK) Cells, Cytokine-Induced Killer (CIK) Cells, Tumor-Infiltrating Lymphocytes (TILs), Macrophages
01
Overview
Immune effector cells are white blood cells that create or enhance an immune response. They play a central role in both innate and adaptive immunity by directly attacking pathogens, infected or malignant cells, or by orchestrating other components of the immune system. They include T cells, B cells, Natural Killer (NK) cells, Cytokine-Induced Killer (CIK) Cells and Tumor-Infiltrating Lymphocytes (TILs).
02
Mechanism of action
Direct cytotoxicity, antibody-mediated cytotoxicity, cytokine secretion, immune modulation
03
Biological functions
Direct killing of infected/cancerous target cells via apoptosisSecretion of cytokines to recruit additional immune effectorsProduction of antibodiesImmune responseClearance of pathogens/tumor burdenRestoration of tissue homeostasis
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Disease associations
CancerInfectionImmunodeficiencyAutoimmune diseases
05
Safety considerations
Cytokine release syndrome (CRS)Neurotoxicity (ICANS)On-target, off-tumor toxicityGraft-versus-host disease (GVHD)ImmunosuppressionTumor lysis syndrome
06
Interacting drugs
CAR-T Cell Therapy
3 more in the full profile.
07
Biomarkers
CD8+CD4+CD25+FOXP3CD56NKG2D/A/C/ECD19CD20IgMCD14CD68
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