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Immune effector cells via Fc receptor modulation
- Molecular classification
- Receptor, Immunoglobulin Receptor, Fc Receptor, Cell Surface Receptor
01
Overview
Immune effector cells, such as NK cells, macrophages, and neutrophils, are regulated through their expression of Fc receptors (FcRs). These receptors bind to the Fc region of antibodies bound to target antigens, triggering immune effector functions like phagocytosis, ADCC, and cytokine release. Modulation of FcR interactions, through protein engineering or glycoengineering of antibodies, is a key strategy for enhancing cancer immunotherapy or reducing unwanted inflammation.
- Other names
- Fc Receptor ModulationFcR ModulationADCC EnhancementImmune Cell Activation via FcRs
02
Mechanism of action
Modulation of Fc receptor binding affinity to enhance or reduce effector cell activity, including phagocytosis, ADCC, and cytokine release.
03
Biological functions
Immune responsePhagocytosisAntibody-dependent cellular cytotoxicity (ADCC)Cytokine releaseInflammation regulationSignal transduction
04
Disease associations
CancerAutoimmunityInflammationInfectionAllergy
05
Safety considerations
Cytokine release syndrome (CRS)Off-target toxicityAutoimmunityHypersensitivity reactions
06
Interacting drugs
Therapeutic antibodies
2 more in the full profile.
07
Biomarkers
FcγR polymorphismsIgG glycoform profilesFcγR expression levels on immune cellsCytokine levels
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