Immune response in skin

"Immune response in skin" is not a specific molecular target but rather refers to the complex network of cells and molecules that mediate immunity within the skin. The cutaneous immune system includes keratinocytes, Langerhans cells, dendritic cells, macrophages, T lymphocytes (including resident and recruited T cells), innate lymphoid cells, eosinophils, neutrophils, and components of the complement system[1][2]. These elements collectively provide both innate and adaptive immunity against pathogens. Keratinocytes act as sentinels by expressing pattern-recognition receptors such as Toll-like receptors to detect pathogens and initiate inflammation[1]. Dendritic cell subsets—including Langerhans cells—present antigens to T lymphocytes to trigger adaptive responses[2]. Innate lymphoid cell subsets contribute to wound healing and tissue homeostasis. The overall function of this system is protection against infection while maintaining tissue integrity; dysregulation can lead to inflammatory diseases or impaired wound healing[1][2]. Because "Immune response in skin" does not refer to a single molecule or druggable target but rather an entire physiological process involving many different cell types and signaling pathways, it should not be considered a canonical therapeutic target for structured data purposes.

Other names

Skin immune responseCutaneous immune responseImmune system in skin