Immune response mediators

Immune response mediators describes a *class of diverse signaling molecules* secreted by cells of the immune system for communication and regulation of immune responses. The primary members are cytokines—including interleukins, interferons, chemokines, and colony-stimulating factors—which *regulate inflammation, cell recruitment, cell proliferation, and pathogen clearance*. These mediators are essential for orchestrating both innate and adaptive immunity as well as maintaining immune homeostasis, but their dysregulation is implicated in a wide range of acute and chronic diseases. The entry "Immune response mediators" does not represent a single analyzable molecular entity and is *not suitable as a canonical drug target*, as it groups together a complex functional category containing many distinct, well-defined therapeutic targets.

Other names

CytokinesInterleukinsInterferonsChemokinesImmune modulatorsImmune mediators

Blockade of cytokine/receptor interaction (e.g., anti-TNF, anti-IL-6); Cytokine receptor antagonism; Neutralization of circulating cytokines; Immune modulation (stimulation or inhibition of immune cell function); Inhibition of cytokine signaling pathways (e.g., JAK/STAT pathway inhibitors)