Immune response-related gene transcripts (IRGs)

Immune response-related gene transcripts represent the diverse collection of messenger RNA (mRNA) molecules transcribed from genes that orchestrate the host's immune system. This broad category includes transcripts encoding cytokines, chemokines, pattern recognition receptors, and major histocompatibility complex (MHC) molecules, which are essential for detecting and responding to pathogens and cellular stress. In clinical and pharmaceutical research, these transcripts are primarily utilized as biomarkers to monitor the immune landscape of tissues, particularly in oncology and autoimmune disorders. While the entire set of transcripts is not a single drug target, individual transcripts within this group are targeted by RNA-based therapeutics, and their collective expression levels are modulated by broad-acting immunomodulatory drugs. Understanding the dynamics of these transcripts is crucial for patient stratification and for evaluating the efficacy of immunotherapies.

Other names

Immune-related genesImmune gene expression profileImmune-related transcriptsImmune response genesInflammatory gene transcripts

Modulation of gene expression through transcriptional regulation, mRNA stability, or signaling pathway inhibition